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Updated: Jan 8, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

Published on: June 13, 2022

カンプトテシンの生合成に触発された不斉全合成

Shan-Shan Li¹, Xiao-Guang Wu¹, Zhen Li¹

¹State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China. tuyq@lzu.edu.cn.

Chemical communications (Cambridge, England)

|December 17, 2025

Abstract:

An asymmetric total synthesis of camptothecin taking advantage of a biosynthetic skeletal transformation is described. The synthesis features an improved one-pot Mannich/acylation/Wittig reaction enabled by a newly developed N-sulfonylated amide catalyst, intramolecular [4+2] cycloaddition, a highly diastereoselective dihydroxylation, and a late-stage scaffold transformation from a monoterpene indole to give a quinoline framework via a Winterfeldt oxidation. These key steps collectively enable a concise and enantioselective synthesis of the antitumor agent (20S)-camptothecin.

キーワード:

カンプトテシン全合成不斉合成触媒有機合成

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