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Updated: Jan 8, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate

Published on: June 21, 2017

クロム／光レドックス二重触媒反応による位置選択的アリルアミノアルキル化の開発

Shiming Tong¹, Wenlong Wang¹, Fu Ye²

¹Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), 1037 Luoyu Road, Wuhan 430074, P. R. China.

Organic letters

|December 17, 2025

Abstract:

A highly branch-regioselective allylic aminoalkylation reaction has been developed through dual chromium/photoredox catalysis, providing an economical and sustainable alternative to conventional methods that rely on noble transition metals, such as palladium. This transformation proceeds under mild conditions and enables the radical coupling of readily accessible allylic bromides with α-silylamines, yielding a diverse range of synthetically valuable branched homoallylic amines. Notably, the method features a broad substrate scope and excellent functional group tolerance, accommodating various aromatic and aliphatic allylic bromides as well as diverse N-heterocyclic amines.

キーワード:

アリルアミノアルキル化クロム触媒光レドックス触媒位置選択性分岐ホモアリルアミン持続可能な合成

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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst

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Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes

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