重度の皮膚反応を伴う患者におけるテモゾロミドによる脱感作の成功例

Patient diagnosed with glioblastoma multiforme undergoing adjuvant treatment with temozolomide, on the 4th day of the seventh adjuvant cycle, developed a widespread erythematous maculopapular rash on the abdomen, back, chest, and facial area. Due to the severity of the condition and the risk of experiencing a similar dermatological reaction, a desensitization protocol with temozolomide was decided to realize based on successful cases worldwide. The patient successfully completed the initially planned 12 treatment cycles, 5 of which involved the desensitization protocol, with only mild symptoms during the first desensitization cycle. Temozolomide desensitization is a successful and safe procedure that enables patients to continue their treatment.