腎疾患における発見から臨床ケアへの橋渡し：基礎研究から臨床応用へ

Acute kidney injury (AKI) pathophysiology and repair are heterogenous processes, and clinical outcomes are difficult to predict. As a result, promising treatments in preclinical models have failed to translate to human subjects, and treatment options for AKI are primarily supportive. To address this, one of the AKI & CRRT 2025 pre-conference symposium plenary sessions showcased cutting edge translational work to guide the scientific community of AKI investigators. Topics included those focused on stratifying risk for AKI reflected in the concept of kidney fitness, characterizing the molecular phenotypes of AKI, improving diagnostics, and identifying novel therapeutic targets. This article provides a review of these topics and a summary of how they address challenges to translating new therapies in AKI from bench to bedside.