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Updated: Jan 8, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
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TFAP2β凝縮をターゲットにすることで,食道状細胞癌の発症を抑制する

Zhaomin Deng1, Lu Pu2, Kai Deng3

  • 1Laboratory of Aging and Cancer, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China; Department of Medical Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.

Cell
|December 17, 2025
PubMed
まとめ

研究者らは,食道状細胞癌 (ESCC) の主要な要因として,転写因子AP-2β (TFAP2β) を特定した. 化合物A6によるTFAP2β凝縮の強化はESCCの進行を抑制し,潜在的な治療戦略を明らかにした.

キーワード:
TFAP2βクロマチンのアクセシビリティ凝縮誘発薬エソファゲスの状細胞癌液体-液体相分離転写因子

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