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研究分野化学科学マクロ分子化学と材料化学超分子化学
損傷遠隔アストロサイトはマイクログリア媒介の白質修復を統制する

損傷遠隔アストロサイトはマイクログリア媒介の白質修復を統制する

Sarah McCallum ^1,2, Keshav B Suresh ^1,2, Timothy S Islam ^1,2, Manish K Tripathi ^1,2, Ann W Saustad ^1,2, Oksana Shelest ³, Aditya Patil ¹, David Lee ¹, Brandon Kwon ¹, Katherine Leitholf ¹, Inga Yenokian ¹, Sophia E Shaka ^1,2, Connor H Beveridge ⁴, Palak Manchandra ⁴, Caitlin E Randolph ⁴, Gordon P Meares ⁵, Ranjan Dutta ⁶, Jasmine Plummer ^1,7, Vinicius F Calsavara ⁸, Riki Kawaguchi ^9,10, Simon R V Knott ^1,11, Gaurav Chopra ^4,12,13, Joshua E Burda ^14,15,16,17

Sarah McCallum ^1,2, Keshav B Suresh ^1,2, Timothy S Islam ^1,2

¹Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
²Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
³Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
⁴Department of Chemistry, Purdue University, West Lafayette, IN, USA.
⁵Department of Neurology, The Neuroscience Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
⁶Department of Neuroscience, Cleveland Clinic, Cleveland, OH, USA.
⁷The Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
⁸Department of Computational Biomedicine Cedars-Sinai Medical Center, Los Angeles, CA, USA.
⁹Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
¹⁰Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
¹¹Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
¹²Department of Computer Science, Purdue University, West Lafayette, IN, USA.
¹³Purdue Institute for Drug Discovery, Regenstrief Center for Healthcare Engineering, Purdue Institute for Cancer Research, Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, USA.
¹⁴Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA. joshua.burda@csmc.edu.
¹⁵Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. joshua.burda@csmc.edu.
¹⁶Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. joshua.burda@csmc.edu.
¹⁷Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA. joshua.burda@csmc.edu.

⁰Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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2025年12月17日

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まとめ

No abstract available on PubMed

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関連する概念動画

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Glial cells are one of the two main types of cells in the nervous system. Glia cells comprise astrocytes, oligodendrocytes, microglia, and ependymal cells in the central nervous system, and satellite and Schwann cells in the peripheral nervous system. These cells do not communicate via electrical signals like neurons do, but they contribute to virtually every other aspect of nervous system function. In humans, the number of glial cells is roughly equal to the number of neurons in the...

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