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Updated: Jan 8, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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GTP放出選択性アゴニストは,オピオイドの鎮痛効果を延長する

Edward L Stahl1, Matthew A Swanson2,3, Vuong Q Dang4

  • 1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. EStahl@usf.edu.

Nature
|December 17, 2025
PubMed
まとめ

Gタンパク質結合受容体 (GPCRs) は,GTPの放出を促進するだけでなく,結合を促すことができる. 特定のアゴニストは選択的にGTPの放出を誘発し,痛みの緩和と副作用を分離する可能性があります.

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