関連する実験動画

Updated: Jan 8, 2026

Preparation of the Mgm101 Recombination Protein by MBP-based Tagging Strategy
11:40

Preparation of the Mgm101 Recombination Protein by MBP-based Tagging Strategy

Published on: June 25, 2013

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RAG媒介の生体内組換えにおけるノナマーコード

Wessal Hanout-Chuiko1, Sunil Pachakar1, Rawan Foqara1

  • 1Azrieli Faculty of Medicine in the Galilee, Bar-Ilan University, Zefat, 1311502, Israel.

Nucleic acids research
|December 18, 2025
PubMed
まとめ

RAG1/2タンパク質はDNA配列を認識することで獲得免疫を開始する。本研究により、コンセンサス配列だけでなく、ノナマー配列がRAG活性とその免疫細胞における標的外効果に大きく影響することが明らかになった。

キーワード:
V(D)J組換えRAG1/2ノナマー配列免疫癌

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The recognition sites for Cre recombinase called LoxP...
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Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
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