非静脈瘤性上部消化管出血:管理における進歩と将来の方向性
Waku Hatta1, Yohei Ogata1, Takashi Chiba2
1Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Clinical endoscopy
|December 18, 2025
まとめ
このレビューは、非静脈瘤性上部消化管出血(NVUGIB)管理の現在のベストプラクティスを強調し、個別化ケアを重視している。主な戦略には、リスク評価、制限的な輸血、内視鏡治療、および難治性症例に対する塞栓術(TAE)の選択的使用が含まれる。
科学分野:
- 消化器病学;内科学;臨床管理
背景:
- 非静脈瘤性上部消化管出血(NVUGIB)に関する多くの臨床ガイドラインが存在するが、推奨内容は大きく異なる。;NVUGIBの効果的な管理には、ケアの複数の段階にわたる構造化されたアプローチが必要である。
研究 の 目的:
- NVUGIB管理に関する最新のエビデンスをレビューし、統合すること。;初期評価から難治性出血管理までのNVUGIB治療戦略の包括的な概要を提供すること。
主な方法:
- NVUGIB管理に関する最近のエビデンスの系統的レビュー。;内視鏡検査前、内視鏡検査中、内視鏡検査後、および難治性出血の各段階にわたる構造化された要約。
主要な成果:
- 内視鏡検査前:リスクスコアは死亡率予測に役立つ;制限的な輸血(7-8 g/dL)と静脈内エリスロマイシンが推奨される。内視鏡検査:様々な止血技術が利用可能;内視鏡検査失敗例では、塞栓術(TAE)が手術よりも優先される。内視鏡検査後:高用量酸抑制療法が重要;再出血に対する反復内視鏡検査が第一選択であるが、TAEの最適なタイミングは議論の余地がある。
結論:
- 多様な臨床像のため、NVUGIBの管理は個別化されるべきである。;NVUGIBに対するエビデンスに基づいた個別化治療戦略の開発には、さらなる研究が必要である。
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