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Updated: Jan 8, 2026

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

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マクロファージ特異のE3ウビキチンリガゼTRIM31は,LOX-1を標的として動脈硬化プラーク形成を減少させる

Jie Zhang1, Liwen Yu1, Wei Yang1

  • 1State Key Laboratory for Innovation and Transformation of Luobing Theory, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China (J.Z., L.Y., W.Y., L.C., X. Wang, C.K., Z.L., R.R., W.Q., L.L., W.X., W.S., X. Wu, N.L., B.L., S.W., P.B., Y.Z., C.Z., M.Z.).

Circulation
|December 18, 2025
PubMed
まとめ

トリパートイトモチーフ含有 31 (TRIM31) は,マクロファージにおけるレクチンのような酸化低密度リポタンパク質受容体-1 (LOX-1) を分解することによって,動脈硬化から保護します. これは泡細胞の形成と炎症を軽減し,TRIM31を治療目標として示唆しています.

キーワード:
動脈硬化症泡細胞炎症マクロファージユビキチネーション

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