脳室内出血患者における血液炎症指数と予後の関連性

The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) are biomarkers of inflammation and immune status. We aimed to investigate the relationship between NLR, MLR, PLR, and atherogenic index of plasma (AIP) levels and prognosis in patients with intracerebral hemorrhage (ICH).

In total, 176 patients with ICH were retrospectively enrolled in this clinical study. Admission blood cell counts were used for the analysis via the hospital automation system. Patients were divided into subgroups according to the hemorrhage type (IPH and SAH), the treatment method (conservative and surgical), and the mortality rates within 48 hours, at 1 month, and 3 months. Blood indices were compared between these subgroups.

The median age was 68 years (56-77), and 108 patients (61.4%) were men. IPH was observed in 154 patients (87.5%), and SAH was present in 22 patients (12.5%). The NLR, MLR, PLR, and AIP values were significantly elevated in IPH patients over those with SAH (P < 0.05); these blood parameter values did not significantly differ between patients who received surgical (8.5%) versus medical (91.5%) treatment. Similarly, these values did not significantly differ between mortality subgroups (P > 0.05).

NLR, MLR, PLR, and AIP values were not associated with prognosis in patients with ICH, a result which does not yet support the use of these markers for short-term risk prediction. Larger cohorts with longitudinal follow-up are needed.