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Updated: Jan 7, 2026

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Published on: April 1, 2022

アルコール誘発性壊死性膵炎：集中治療室入室予測因子としての血清リン酸値に関する後向き研究

Usamah Al-Anbagi¹, Abdulrahman Saad², Abdelkarim H Mohamed¹

¹Internal Medicine, Hamad Medical Corporation, Doha, QAT.

|December 19, 2025

要旨

Background:

Alcohol-induced acute pancreatitis remains a major cause of hospitalization globally. While most cases resolve without complication, a subset progresses to necrotizing pancreatitis requiring intensive care. Identifying early biochemical predictors of severe disease can improve triage and management.

Methods:

We conducted a retrospective observational study at Hazm Mebaireek General Hospital, Qatar, including adult male patients diagnosed with alcohol-induced necrotizing pancreatitis between May 2020 and May 2025. Data were extracted from electronic medical records, including demographic, clinical, biochemical, and radiologic variables. The association between hypophosphatemia (serum phosphate <0.8 mmol/L) and intensive care unit (ICU) admission was explored descriptively.

Results:

Fifteen patients were included (mean age: 38 years). Hypophosphatemia occurred in 60% of cases and was strongly associated with ICU admission (eight of nine ICU patients, 89%). Common complications included pleural effusion (40%), splenic vein thrombosis (20%), and acute kidney injury (13%). Patients with hypophosphatemia exhibited higher BISAP scores, prolonged hospitalization, and greater morbidity.

Conclusion:

Hypophosphatemia is a frequent finding in alcohol-induced necrotizing pancreatitis and may serve as a simple, inexpensive early marker of disease severity. Routine phosphate measurement upon admission may help identify patients at risk for deterioration and guide timely intervention.

キーワード:

アルコール誘発性膵炎低リン酸血症集中治療壊死性膵炎リン酸カタール

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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

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