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関連する概念動画

Proteomics01:33

Proteomics

9.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Protein Networks02:26

Protein Networks

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
Ribosome Profiling02:24

Ribosome Profiling

4.0K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
4.0K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

1.3K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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Protein-protein Interfaces02:04

Protein-protein Interfaces

14.4K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

2.8K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
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関連する実験動画

Updated: Jan 8, 2026

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
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Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Published on: April 11, 2019

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抗原と新規機能性タンパク質の間の暗号化プロテオームの解読

Emma G Bawden1, Sebastian Amigorena1, Yago A Arribas1

  • 1Inserm U932 Immunity and Cancer, Institut Curie, PSL University, Paris, 75005, France.

European journal of immunology
|December 19, 2025
PubMed
まとめ
この要約は機械生成です。

非コードゲノム由来の暗号化タンパク質により、ヒトプロテオームの複雑性が増大します。これらのタンパク質は、免疫監視のための抗原の供給源となり、進化のための機能性タンパク質の多様性を拡大します。

キーワード:
DRiPs抗原提示暗号化プロテオーム免疫ペプチドゲノミクスリボソームプロファイリング

さらに関連する動画

Identification of Functional Protein Regions Through Chimeric Protein Construction
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Identification of Functional Protein Regions Through Chimeric Protein Construction

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An Integrated Approach for Microprotein Identification and Sequence Analysis
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An Integrated Approach for Microprotein Identification and Sequence Analysis

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関連する実験動画

Last Updated: Jan 8, 2026

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
07:38

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Published on: April 11, 2019

13.3K
Identification of Functional Protein Regions Through Chimeric Protein Construction
11:39

Identification of Functional Protein Regions Through Chimeric Protein Construction

Published on: January 8, 2019

10.9K
An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

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科学分野:

  • ゲノミクス; プロテオミクス; 免疫学

背景:

  • ヒトゲノムには、以前は機能がないと考えられていた広大な非コード領域が含まれています。
  • 最近の発見では、非コードDNAからの暗号化タンパク質の翻訳が示されており、プロテオームの複雑性が拡大しています。
  • これらのタンパク質は、しばしば低レベルで発現し、急速に分解され、MHC-I上に提示されます。

研究 の 目的:

  • ヒトプロテオームの進化と免疫監視における暗号化タンパク質の役割を説明するモデルを提案すること。
  • 暗号化タンパク質が機能性タンパク質の多様性にどのように貢献するかを調査すること。
  • 免疫監視のための抗原の供給源を理解すること。

主な方法:

  • 暗号化タンパク質の翻訳とその進化的影響の理論的モデリング。
  • タンパク質の発現、分解、およびMHC-I提示経路の分析。
  • 非コードゲノム翻訳と免疫学に関する既存の文献のレビュー。

主要な成果:

  • 暗号化タンパク質は、進化選択に利用可能な機能性タンパク質の多様性を増加させます。
  • 暗号化タンパク質の一部は安定かつ機能的であり、プロテオームに統合される可能性があります。
  • 暗号化タンパク質は、免疫系の監視のための抗原の供給源として機能します。

結論:

  • 暗号化タンパク質の翻訳は、プロテオームの拡大と進化における重要な要因です。
  • 暗号化タンパク質は、機能的多様性の拡大と免疫監視のための抗原の提供という二重の役割を果たします。
  • このプロセスは、非コードゲノム、タンパク質進化、および免疫応答の間の動的な相互作用を強調しています。