エプティネズマブ脱感作の最初の成功プロトコル

Benoit Gerard¹, Hubert Praudel¹, Michel Lanteri-Minet^2,3

¹Département de pneumologie et d'oncologie thoracique, Centre Hospitalier Universitaire de Nice, IHU RespirERA, Université Côte d'Azur, Nice, France.

Headache

|December 20, 2025

要旨

Background:

Eptinezumab is an anti-calcitonin gene-related peptide monoclonal antibody used for migraine prevention. During clinical trials, hypersensitivity to eptinezumab was described without a clear underlying mechanism. To determine if the reaction was immunoglobulin E-mediated, the team of Nice University Hospital (Nice, France) performed the eptinzeumab skin tests. A 10-step desensitization protocol has been proposed to manage these reactions.

Findings:

Two patients presenting with immediate hypersensitivity reactions underwent the eptinezumab skin test. Neither skin test was positive, suggesting a non-immunoglobulin E-mediated mechanism. The patients then completed the desensitization protocol successfully.

Conclusion:

This hospital-based 10-step desensitization protocol appears safe and effective.

キーワード:

アレルギー脱感作エプティネズマブ皮膚テスト

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