乳房再建におけるリポソーム化ブピバカインは術後のオピオイド使用量を削減するか?
Thomas Ren1, Andre Galenchik-Chan2, Nicolas Oltean2
1Renassaince School of Medicine, Stony Brook University, Stony Brook, NY, USA. thomas.ren@stonybrookmedicine.edu.
Aesthetic plastic surgery
|December 20, 2025
まとめ
ExparelはMarcaineと比較して乳房再建患者のオピオイド使用量を大幅に削減しました。この術後回復強化(ERAS)アプローチは、オピオイド鎮痛管理に関連するリスクを低減する可能性があります。
科学分野:
- 形成外科;麻酔科学;疼痛管理
背景:
- 乳房再建における術後オピオイド使用は、重大な副作用をもたらします。;術後回復強化(ERAS)プロトコルは、オピオイド消費量の最小化を目指しています。;地域麻酔ブロックはERASプロトコルの重要な構成要素です。
研究 の 目的:
- 乳房再建後の術後オピオイド使用量削減におけるExparelとMarcaineの効果を比較すること。;乳房再建後の疼痛管理に対するリポソーム化ブピバカインの影響を評価すること。
主な方法:
- 163人の乳房再建患者(2019年1月~2022年6月)の後ろ向き研究。;患者は地域麻酔のためにMarcaineまたはExparelのいずれかを受けました。;オピオイド処方箋を追跡し、モルヒネ換算量(MED)に変換しました。
主要な成果:
- Exparel群はMarcaine群(160.53 ± 150.58 MED)と比較して、有意に低いオピオイド消費量(97.21 ± 81.77 MED)を示しました。;Exparel群は、総処方オピオイド数が少なかった(1.35対1.90)。;乳房再建の種類に基づく有意差は認められませんでした。
結論:
- Exparelは、乳房再建においてMarcaineと比較して術後のオピオイド必要量を大幅に削減します。;この発見は、乳房再建のためのERASプロトコルにおけるExparelの役割を支持します。;Exparelの使用は、患者の回復を強化し、オピオイド関連の有害事象を軽減する可能性があります。
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