アダプティブセンシングのための生物学的複雑さに触発された高強度・異方性タンパク質ベース材料のエンジニアリング

Biological systems inspire the design of high-performance biomimetic materials, yet replicating their synergistic interactions and hierarchical structures remains challenging. Here, we present an orthogonal photochemistry-mediated strategy for one-step fabrication of muscle-inspired protein materials. This approach integrates covalent, electrostatic, and hydrogen-bonding interactions to form robust multinetwork architectures within hierarchically organized protein matrices. Prestretching enhances molecular alignment, yielding anisotropic materials with a factor of 3.0, tensile strengths up to 300 MPa, toughness over 22 MJ m^-3, and a fatigue threshold of 760 J m^-2─surpassing natural proteins such as wool, cotton, and silk. The rapid (∼20 s), precisely controllable process supports scalable 3D manufacturing of continuous fibers exceeding 10 m. Beyond mechanical robustness, the materials dynamically respond to force, humidity, and pH, mimicking biological tissues. As a proof of concept, the fibers function as artificial muscles and flexible capacitive sensors, highlighting their potential for advanced applications in biomaterials, bioengineering, and soft electronics.