粒子状物質大気汚染およびその成分への長期曝露と乳がんリスク：E3N-Generationsコホートにおけるネストされた症例対照研究

Previous studies on the association between airborne particulate matter (PM), particularly PM_2.5 and PM₁₀, and breast cancer have shown inconsistent results, potentially due to variations in particle composition. To address this, we investigated the relationship between breast cancer and exposure to individual PM_2.5 and PM₁₀ components, as well as their combined effects, in the French E3N-Generation cohort.

We conducted a nested case-control study within the cohort (1990-2011), including 5,222 incident breast cancer cases matched to 5,222 controls. Annual mean concentrations (µg/m³) of pollutants at residential addresses were estimated using the CHIMERE chemistry-transport model from 1990 to the index date. Exposure assessment included nine PM components: ammonium, sulfate, black carbon, polychlorobiphenyl-153 (PCB153), nitrate, benzo[a]pyrene, cadmium, dioxins, and Saharan dust. We evaluated single-pollutant effects using logistic regressions, and mixture effects using Quantile G-computation (QGC) and Bayesian Kernel Machine Regression (BKMR).

Significant positive associations with breast cancer (Odds Ratios and confidence intervals for one SD increase (controls distribution) were found for ammonium (OR = 1.19; 95%CI: 1.05-1.35), sulfate (OR = 1.17; 95%CI: 1.02-1.35), PCB153 (OR = 1.17; 95%CI: 1.08-1.26), nitrate (OR = 1.16; 95%CI: 1.01-1.33), black carbon (OR = 1.12; 95%CI: 1.05-1.20), cadmium (OR = 1.05; 95%CI: 1.00-1.11). QGC showed a positive association with breast cancer for a one-quartile increase in joint exposure (OR = 1.22; 95% CI: 1.00-1.50) with cadmium and nitrate as major contributors. BKMR confirmed a significant positive association between the exposure to the mixture and breast cancer.

The consistency between single-pollutant and mixture analyses supports a role for multiple PM components acting jointly on breast cancer risk. These results suggest that the chemical composition of PM, rather than individual pollutants alone, is a key determinant of breast cancer risk, highlighting the importance of considering pollutant composition in air pollution research.