Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Complement System01:27

Complement System

9.5K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
9.5K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.9K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.9K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.2K
Humoral Immune Responses01:36

Humoral Immune Responses

83.2K
Overview
83.2K
Antimicrobial Proteins01:23

Antimicrobial Proteins

12.9K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
12.9K
Complementation Tests00:49

Complementation Tests

6.0K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.0K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

A case of Incontinentia Pigmenti associated with concurrent <i>IKBKG/NEMO</i> and <i>MED13L</i> mutations.

Frontiers in medicine·2026
Same author

BIRC3 (Encoding Cellular Inhibitor of Apoptosis Protein 2) Variants Result in Dysregulated Receptor-Interacting Protein Kinase 1 Signaling Leading to Increased Epithelial Cell Death and Are Associated With Monogenic Crohn's Disease.

Gastroenterology·2026
Same author

Expanding the clinical spectrum of RNU4ATAC-opathies: more frequent and diverse than assumed.

Genetics in medicine : official journal of the American College of Medical Genetics·2026
Same author

Immune microenvironment and noncoding RNA shape early colorectal carcinogenesis in patients with premalignant lesions.

Science translational medicine·2026
Same author

STAT2 R148 variant: A 16th-century founder mutation and clinical response to high-dose JAK inhibitor therapy.

Journal of human immunity·2026
Same author

Death following high-dose AAV9 gene therapy in a patient with advanced SMA-PME.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same journal

Noncanonical ion channel signaling in neurovascular barrier regulation and immune cell trafficking.

Current opinion in immunology·2026
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
関連記事をすべて見る

関連する実験動画

Updated: Jan 8, 2026

Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.6K

補体欠損症と感染症

Carine El Sissy1, Jérémie Rosain2, Mathilde Puel3

  • 1Department of Immunology, Assistance Publique, Hôpitaux de Paris (AP-HP), Georges Pompidou European Hospital, Paris, France; University of Paris Cité, Paris, France; Inflammation, Complement and Cancer Team, Cordeliers Research Center, Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche UMRS1138, Paris, France; COMET "Complement Expertise and Therapeutics", Fédération Hospitalo-Universitaire, Paris, France.

Current opinion in immunology
|December 20, 2025
PubMed
まとめ
この要約は機械生成です。

補体欠損症は感染リスクを高め、特に被膜細菌による感染のリスクが増加する。補体介在性疾患を管理する新しい治療法では、感染症の注意深いモニタリングと、ワクチン接種などの積極的な予防戦略が必要となる。

キーワード:
補体欠損症感染症自然免疫補体阻害療法診断ワクチン接種メニゴコッカス感染症ニューモコッカス感染症

さらに関連する動画

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry
07:20

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry

Published on: May 19, 2020

7.6K
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

31.1K

関連する実験動画

Last Updated: Jan 8, 2026

Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.6K
Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry
07:20

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry

Published on: May 19, 2020

7.6K
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

31.1K

科学分野:

  • 免疫学
  • 感染症学

背景:

  • 補体系は自然免疫に不可欠であり、病原体の除去や免疫応答の調節に関与しています。
  • 補体タンパク質の欠損は、特にナイセリア・メンインギチディスやストレプトコッカス・ニューモニエなどの被膜細菌に対する重度の感染症への感受性を高めます。

研究 の 目的:

  • 補体欠損症の臨床的および機序的側面をレビューすること。
  • 補体阻害療法に関連する感染リスクについて議論すること。
  • 補体欠損症の現在の診断戦略を概説すること。

主な方法:

  • 補体欠損症および治療に関する臨床研究と機序的研究の文献レビュー。
  • 機能的および定量的アッセイを含む診断アプローチの分析。
  • 補体遮断に関連する感染合併症の評価。

主要な成果:

  • 補体欠損症は、重度の細菌感染症、自己免疫疾患、腎疾患のリスクを高めます。;補体阻害療法は補体介在性疾患に有効ですが、髄膜炎菌感染症や侵襲性真菌感染症のリスクを増加させます。;特殊なアッセイによる早期診断は、再発性または早期発症の感染症患者の管理において極めて重要です。

結論:

  • 補体欠損症の理解は、関連する感染症や自己免疫疾患の管理に不可欠です。
  • 治療的な補体阻害は、新たな感染リスクに対する注意深いモニタリングと予防策の実施を必要とします。
  • 補体を標的とする治療法の進歩に伴い、予見的なケア、ワクチン接種、予防が不可欠です。