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Updated: Jan 7, 2026

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

Published on: December 9, 2022

慢性重症虚血肢患者における超高齢者と正常高齢者の臨床的特徴：単一施設での実体験レトロスペクティブ研究

Ke Wang¹, Haijun Wei¹, Qiqi Wang¹

¹Department of Vascular Surgery, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China.

European journal of medical research

|December 20, 2025

要旨

Background:

The benefit of endovascular therapy (EVT) for chronic limb-threatening ischemia (CLTI) in patients aged ≥ 80 years (extremely elderly) is debated. This study compared outcomes between extremely elderly and younger elderly (60-79 years) patients.

Methods:

In this retrospective study, 367 patients (133 ≥ 80y, 234 60-79y) undergoing EVT were analyzed. Propensity score matching balanced baseline characteristics. Primary endpoints were one-year major adverse limb events (MALEs) and mortality. Univariate Cox analysis identified MALE-associated factors.

Results:

After matching, the ≥ 80y group had more complex lesions (longer occlusions, poorer runoff). Their one-year freedom from MALEs (44.721% vs 61.697%, p = 0.053) and freedom from mortality rates(77.191% vs 85.628%, p = 0.215) were lower. Univariate analysis indicated age ≥ 80y (HR = 1.55, 95% CI 1.01-2.38, P = 0.043) and TASC II C/D lesions (HR = 1.26, 95% CI 1.02-1.55, P = 0.035) increased MALE risk, while drug-coated balloons((HR = 0.69, 95% CI 0.56-0.85, P = 0.001). and Lipid lowering agents usage (HR = 0.59, 95% CI 0.36-0.98, P = 0.041) were protective. Postoperative psychiatric symptoms were more frequent in the ≥ 80y group. Critically, both groups showed significant and comparable improvements in pain scores and functional capacity after EVT.

Conclusions:

Despite higher risks, EVT meaningfully improves quality of life in extremely elderly CLTI patients. Treatment should not be denied based on age alone, but should be individualized considering the higher anatomical complexity.

キーワード:

有害な四肢イベント合併症超高齢末梢血管疾患傾向スコアマッチング生活の質

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Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

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