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Updated: Jan 7, 2026

An Efficient and Flexible Cell Aggregation Method for 3D Spheroid Production

An Efficient and Flexible Cell Aggregation Method for 3D Spheroid Production

Published on: March 27, 2017

球状成分集合体のモデリングのためのジオメトリ認識点群クラスタリング

Yuta Muramatsu¹, Syuhei Sato^2,3, Kaisei Sakurai⁴

¹Faculty of Computer and Information Sciences, Hosei University, Tokyo, 184-8584, Japan.

Scientific reports

|December 20, 2025

Abstract:

This paper proposes a method for obtaining independent mesh models of individual components from a point cloud representing an aggregate. An aggregate consists of a collection of small, similar components, such as individual grapes in a bunch. Typical shape reconstruction creates a rough shape of the entire bunch, but fails to recover individual components from the bunch due to occlusion and missing points for shapes. To achieve this type of modeling, we assume that each component can be approximated as a spherical shape. Leveraging this assumption, we develop geometry-aware clustering that identifies and segments individual components from the aggregate. During this procedure, we search for the optimal position and size of a predefined aggregate component that best fits the cluster. When overlapping components are detected, the corresponding clusters are merged. We demonstrate the effectiveness of the proposed method by applying it to several types of aggregates, such as grapes and tomatoes.

キーワード:

3D再構成集合体モデリング点群

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