急性骨髄性白血病（AML）におけるマイクロバイオームのジスバイオシスと化学療法の耐性

Maojin Tian¹, Hamed Soleimani Samarkhazan², Seyed Shahabedin Alemohammad³

¹Zibo Central Hospital, Binzhou Medical University, Zibo, Shandong, China. phytian@163.com.

|December 21, 2025

Abstract:

AML often relapses due to chemotherapy resistance, increasingly linked to gut microbiome dysbiosis. Microbial drug modification, immune modulation, and metabolite-driven survival/epigenetic changes (e.g., SCFAs, kynurenine) promote resistance. Clinical data associate reduced diversity, loss of Faecalibacterium, and Enterococcus overgrowth with poorer outcomes. Microbiome interventions (FMT, probiotics, diet) show promise; priorities are standardizing methods and defining microbe-metabolite mechanisms to guide trials.

キーワード:

腸内細菌叢急性骨髄性白血病化学療法耐性マイクロバイオームジスバイオシス

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