全身性エリテマトーデスの成人における尿失禁
Gabriel Salazar1, Scott Bauer1,2,3, Courtney Hoge4
1Department of Medicine, University of California, San Francisco.
ACR open rheumatology
|December 21, 2025
まとめ
尿失禁(UI)は全身性エリテマトーデスの患者の3分の1以上に影響を及ぼし、疾患活動性の高さと関連しています。この集団における早期のスクリーニングと管理が重要です。
科学分野:
- リウマチ学;泌尿器科学;疫学
背景:
- 全身性エリテマトーデスの尿失禁(UI)の有病率と影響は十分に文書化されていません。患者ケアと生活の質の向上には、SLEにおけるUIの理解が不可欠です。
研究 の 目的:
- 米国ベースのSLEコホートにおけるUIの有病率と生活負担を決定すること。UIとSLEの疾患活動性および損傷との関連を調査すること。
主な方法:
- UI評価のためのアンケートに回答した425人のSLE患者(平均年齢46.3歳、92.0%が女性)のコホート。SLEの活動性と損傷を測定し、ロジスティック回帰でUIとの関連を分析しました。UIは毎月の尿漏れと定義され、疾患指標は中央値で二分されました。
主要な成果:
- SLE患者の36.2%が毎月のUIを報告し、混合型が最も一般的でした。UIは女性、高齢者、肥満のある人でより一般的でした。SLEの疾患活動性が高いとUIのオッズが有意に増加しました(OR=3.02)。疾患の損傷は有意でない傾向を示しました。
結論:
- UIはSLE患者に共通する状態であり、疾患活動性の増加と有意に関連しています。本研究の結果は、SLEにおけるUIの最新の臨床スクリーニングおよび管理プロトコルの必要性を強調しています。UIに対処することで、SLEを持つ個人の日常生活と全体的な健康転帰を改善できます。
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