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Updated: Jan 8, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

COVID-19：健常若年者における重度の神経認知障害：症例シリーズ

Akram Farhat¹, Firas Jaber², Nazih Jaber³

¹Clinical Research Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Clinical medicine insights. Case reports

|December 22, 2025

要旨

Background:

A growing number of patients suffering from neurocognitive symptoms related to COVID-19 were observed as the pandemic progressed. This article addresses severe neurological manifestations in healthy individuals with COVID-19, which were not previously identified in the absence of comorbidities or respiratory symptoms.

Case Presentations:

The 3 patients, aged between 15 and 27 years old, had no relevant medical history and were not on any chronic treatments. They presented different neurological symptoms (pseudobulbar affect, excessive crying, paracusia, fatigue and sleep problems, anxiety, depression, alexithymia, dementia, aggressive behavior, panic attack, etc) for a period of 2 weeks to 4 months and were treated with different medications. Clomipramine, Zolpidem and Clonazepam were effective in treating these patients.

Conclusion:

Even in healthy young individuals with COVID-19, severe neurocognitive manifestations could appear with possible long-term consequences. Further research is needed to expand the knowledge on mechanisms, targeted therapeutic strategies and predictors identifying at-risk groups.

キーワード:

COVID-19 症例報告精神障害神経学的徴候若年成人

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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

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