ニューリチン：神経変性疾患への新たな応用が期待される多面的な神経保護因子

¹Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States.

|December 22, 2025

Abstract:

Neuritin is a conserved, activity-regulated gene encoding a glycosylphosphatidylinositol-anchored protein, crucial for neural development, synaptic plasticity, and neuroprotection. Identified via activity-dependent gene screening in the rat hippocampus, neuritin promotes neurite outgrowth, dendritic arborization, and synaptic maturation with neural activity. In this review, we summarize recent findings regarding neuritin's signaling pathways, neuroprotective, neuroregenerative, and neuromodulatory properties, with a focus on its therapeutic potential to counter neurodegeneration in various conditions such as glaucoma, Alzheimer's disease, stroke, diabetic neuropathy, and neuropsychiatric disorders. Additionally, recent studies reveal roles in immunoregulation, angiogenesis, and cancer biology, highlighting neuritin as a versatile signaling molecule with broad therapeutic implications.

キーワード:

ニューリチン神経変性神経保護網膜神経節細胞シナプス可塑性

さらに関連する動画

10:12

Designing Porous Silicon Films as Carriers of Nerve Growth Factor

Published on: January 25, 2019

10.1K

09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

11.2K

関連する概念動画

01:15

Neurogenesis and Regeneration of Nervous Tissue

1.5K

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

1.5K

01:00

Enzyme-linked Receptors

85.6K

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...

85.6K