エンドテリオパチーを伴う敗血症性ショック患者の免疫表現型：単球サブタイプと免疫調節分子に焦点を当てる

Septic shock is characterized by dysregulation of the host response to infection Q5 which results in life-threatening organ dysfunction that can be partly attributed to immune alterations and endothelial dysfunction (endotheliopathy). This lethal condition is dynamic, complex, and heterogeneous.

Thus, an exploratory broad phenotypic and functional analysis of circulating immune cells and mediators were carried out to better understand the role of the immune system in a subgroup of septic shock patients with endotheliopathy defined by increased levels of soluble thrombomodulin (sTM). In this regard, especially the immune status of monocyte subtypes (classical, intermediate, and nonclassical) was investigated for surface thrombomodulin (TM), MHC class II molecules (HLADR, -DQ, and -DP) and immunomodulatory surface receptors (TREM-1, CD137, VISTA, HVEM and BTLA).

Our comprehensive immunophenotypic analysis on a septic shock cohort with endotheliopathy identified distinct immune perturbation patterns that potentially can lead to novel treatment avenues in the management of this life-threatening condition.