抗インターフェロンγ自己抗体と判定不能なQuantiFERON®-TB Gold Plusアッセイ
Serena Lee1, Annalie J Harris1, Christa S Zerbe1
1Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, Maryland, USA.
Abstract:
Among 852 samples sent for QuantiFERON®-TB Gold Plus Assay (QFN) analysis, between 6% and 11% had IFNγ binding activity, but only 1.2% of indeterminate samples had IFNγ blocking activity. No TB negative samples had blocking activity to IFNγ. Indeterminate QFN results may indicate the presence of blocking anti-IFNγ autoantibodies.
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