ホルミル化胆汁酸-ステロイド抱合体：合成、抗真菌特性、およびインシリコ研究

Grzegorz Hajdaś¹, Damian Kułaga², Hanna Koenig¹

¹Department of Bioactive Products, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8 Street, Poznań 61-614, Poland.

|December 22, 2025

Abstract:

Fungal infections caused by Alternaria alternata, Fusarium culmorum (F. culmorum), and Botrytis cinerea (B. cinerea) pose significant risks to agriculture and human health. The emergence of fungicide resistance underscores the need for new antifungal agents. Bile acid-steroid conjugates, synthesized via "click chemistry", offer a promising solution due to their stability and biological activity. In this study, bile acid derivatives linked by 1,2,3-triazole rings were synthesized and evaluated for antifungal activity. Spectroscopic analysis confirmed successful conjugation, and molecular docking studies identified interactions with fungal targets. Biological assays revealed potent antifungal effects, especially against F. culmorum and B. cinerea, with compounds (23) and (24) showing the strongest activity. These findings highlight the potential of bile acid derivatives as novel antifungal agents, and further optimization could enhance their efficacy and selectivity for therapeutic applications.

キーワード:

胆汁酸ステロイド抱合体抗真菌真菌剤耐性クリックケミストリーフサリウム・クルモルムボトリティス・シネレア

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