糖尿病関連末梢神経障害を有する猫の感覚プロファイル

Hélène L M Ruel^1,2, Vanessa Bruneau¹, Berenice Conversy¹

¹Le Centre hospitalier universitaire vétérinaire, Faculty of Veterinary Medicine, Université de Montréal, St-Hyacinthe, Quebec, Canada.

The Veterinary record

|December 22, 2025

要旨

Background:

Diabetes mellitus (DM) can cause peripheral neuropathy. This study aimed to evaluate sensory function by measuring the mechanical nociceptive thresholds (MNT) and diffuse noxious inhibitory control (DNIC) of cats with diabetes mellitus (DM_cats).

Methods:

Eight cats with DM and 12 healthy controls were included in a prospective, randomised study. MNT were measured by applying pressure against the metatarsal pad (MNT_bio). MNT were also measured using a mechanical actuator attached to one of the cat's pelvic limbs (MNT_top). The DNIC was assessed by comparing MNT_top before and after a conditioning stimulus.

Results:

MNT_bio of the controls were significantly lower (2.1 ± 0.7 N) than those of DM_cats (3.6 ± 1.2 N). DNIC and MNT_top were not different between groups.

Limitations:

This study had a small cohort of patients and an MNT cut-off to prevent injuries.

Conclusion:

DM_cats showed hypoalgesia and loss of sensory function. This study could not differentiate DNIC between healthy and those with DM.

キーワード:

糖尿病性ニューロパチーネコ低痛覚痛み感覚プロファイル

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