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Updated: Jan 8, 2026

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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
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高気圧酸素療法の耳科系有害事象に関するシステマティックレビュー
Andrew Voigt1,2,3, Matteo Laspro4, Erika Thys3,5
1SUNY Downstate Health Sciences University, New York, NY.
まとめ
高気圧酸素(HBO₂)療法を受けた患者の15%が、主に中耳気圧外傷(MEB)の耳科系合併症を経験した。リスク因子には高齢や既存の状態が含まれ、効果的な耳抜き技術は保護的である。
科学分野:
- 耳鼻咽喉科; 高気圧医学; 系統的レビュー
背景:
- 高気圧酸素(HBO₂)療法は、耳科系合併症を含む潜在的なリスクに関連しています。これらの合併症の発生率に関する以前の研究ではばらつきが見られました。リスク因子と保護因子の包括的な理解が必要です。
主な方法:
- PRISMA 2020ガイドラインに準拠した系統的レビュー。タイトルと抄録のスクリーニングの後、全文分析。耳科系合併症の発生率およびリスク/保護因子を報告する研究の包含。
結論:
- 耳科系合併症は、HBO₂療法を受けている患者の15%に影響します。高齢、女性、および特定の既存の状態はMEBのリスクを高めます。強化されたモニタリングと適切な耳抜き技術はMEBのリスクを軽減できます。
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