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Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Published on: August 1, 2025
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米国における青少年大麻使用
Ryan S Sultan1,2,3, Alexander W Zhang1, Timothy D Becker1,2
1Department of Psychiatry/New York State Psychiatric Institute, Columbia University Vagelos College of Physicians and Surgeons, New York, New York.
Pediatrics
|December 22, 2025
まとめ
青少年の大麻使用頻度は、低頻度であっても、学業および情緒面での悪影響と関連している。これらの所見は、若者の大麻使用状況の定期的なスクリーニングの必要性を強調するものである。
科学分野:
- 青年発達; 大麻使用と精神的健康; 心理社会的指標
背景:
- 青年期は重要な発達段階である。青少年の心理社会的発達に対する大麻使用の用量依存的な影響に関するデータは限られており、特に非頻度使用者についてはそうである。これらの関連性を理解することは、標的を絞った介入にとって重要である。
研究 の 目的:
- 大麻使用頻度と青少年の心理社会的発達指標との間の用量依存的な関係を調査すること。様々なレベルの大麻消費に関連する特定の有害転帰を特定すること。青少年の大麻使用に関する公衆衛生戦略に情報を提供すること。
主な方法:
- 米国の8年生、10年生、12年生(2018-2022年)の全国代表サンプルを利用した横断研究。参加者は、非使用、非現在、月間、週間、ほぼ毎日の大麻使用グループに分類された。心理社会的指標について、人口統計学的に調整されたオッズ比と効果量が計算された。
主要な成果:
- 162,532人の学生の26%以上が大麻使用を報告した。非現在使用者および月間使用者は、非使用者と比較して、学業成績の低下、衝動性、自己制御の問題、および情緒状態の悪化のオッズ増加を示した。ほとんどの有害な心理社会的転帰において用量反応傾向が観察され、若年使用者(16歳未満)はより大きな感受性を示した。
結論:
- 青少年の学業および情緒機能に対する大麻使用頻度と有害な影響との間の用量依存的な関連は、月間使用であっても明らかである。これらの所見は、青少年の医療における大麻使用の定期的なスクリーニングの重要性を強調する。早期介入と予防の取り組みは、否定的な心理社会的影響を軽減するために極めて重要である。
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