病原性細菌の化学的防除：新規化合物、分子標的、および展望

Phytopathogenic bacteria are responsible for devastating agricultural losses globally. However, the chemical control of these pathogens is compromised by escalating resistance, environmental pollution, antibiotic resistance gene transfer, and a scarcity of validated antibacterial targets. To fill this gap, this review provides a critical and chemically-focused discussion of recent breakthroughs, aiming to bridge the gap between synthetic innovation, modern target discovery, and rational, data-driven design. Herein, we delineate emerging antibacterial compounds, emphasizing their structural diversity, structure-activity relationships, novel modes of action, and molecular targets. Furthermore, advanced methodologies for discovering and validating antibacterial targets are thoroughly examined, along with deep mechanistic insights. A forward-looking perspective on transformative approaches is also provided. This review aims to guide interdisciplinary efforts and stimulate the development of effective, sustainable, and environmentally friendly next-generation phytobactericides by offering the analysis urgently required by the field.