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Updated: Jan 8, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

小児てんかんにおけるバルプロ酸の血清BDNFおよびMMP-9への影響

Anand Borisagar¹, Rachna Gupta¹, Manish Narang²

¹Department of Pharmacology, University College of Medical Sciences (University of Delhi) & GTB Hospital, New Delhi, India.

Journal of epilepsy research

|December 23, 2025

要旨

Background And Purpose:

In recent years, brain-derived neurotrophic factor (BDNF) and matrix metalloproteinase-9 (MMP-9) have garnered interest for their involvement in epilepsy. This study evaluated the serum levels of BDNF and MMP-9 in pediatric patients with epilepsy compared to healthy controls and assessed the effect of valproate on serum BDNF and MMP-9.

Methods:

Children aged 1 year to 12 years, diagnosed with epilepsy (n=30), and age-matched healthy controls (n=30) were included. All participants were followed up for 16 weeks and assessed for changes in serum BDNF and MMP-9 levels.

Results:

Children with epilepsy had significantly lower BDNF and higher MMP-9 levels compared to healthy controls at baseline. Following 16 weeks of treatment with valproate, BDNF levels were increased significantly (p<0.001), and MMP-9 levels decreased significantly (p<0.001).

Conclusions:

The findings suggest the involvement of BDNF and MMP-9 in the pathogenesis of epilepsy. Serum BDNF and MMP-9 levels were increased and decreased, respectively, following valproate treatment in children with epilepsy. Hence, BDNF and MMP-9 could be potential biomarkers in pediatric epilepsy. Large sample sizes and long-term studies are warranted to confirm the findings.

キーワード:

脳由来神経栄養因子てんかんマトリックスメタロプロテアーゼ9 バルプロ酸

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