Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Stringent Response in E. coli01:23

Stringent Response in E. coli

257
Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
257
Bacterial Phylum Firmicutes01:27

Bacterial Phylum Firmicutes

867
Firmicutes is a diverse phylum of Gram-positive bacteria characterized by a low GC content in their genomes. This phylum includes organisms with monoderm or diderm cell envelopes, highlighting a complex evolutionary history. Firmicutes comprises several major orders, including Lactobacillales, Clostridiales, and Bacillales, which exhibit remarkable diversity in their morphology, metabolism, and ecological roles.The order Lactobacillales includes lactic acid bacteria, which are fermentative...
867
Other Stress Responses in Bacteria01:30

Other Stress Responses in Bacteria

310
Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...
310
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

457
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
457
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

1.5K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.5K
Chemotaxis in E. coli01:27

Chemotaxis in E. coli

626
Chemotaxis in Escherichia coli is a sensory-driven motility mechanism that enables bacteria to navigate chemical gradients, moving toward beneficial environments while avoiding harmful conditions. This process relies on a signal transduction system integrating external chemical cues with flagellar motor control.Chemoreceptors and Signal DetectionE. coli detects chemical gradients through methyl-accepting chemotaxis proteins (MCPs), which are membrane-bound chemoreceptors that sense attractants...
626

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2026
Same author

Phase variable colony morphotypes of <i>Clostridioides difficile</i> elicit distinct host responses during acute infection.

Infection and immunity·2026
Same author

T cell dysregulation and remodeling in pediatric obesity and weight loss.

bioRxiv : the preprint server for biology·2026
Same author

Glucuronidation metabolomic fingerprinting to map host-microbe metabolism.

Nature communications·2026
Same author

Metabolic and transcriptional plasticity supports CD8<sup>+</sup> T cell resilience and anti-tumor immunity under nutrient stress.

Immunity·2026
Same author

Pharmacological reduction of neutrophil infiltration reduces <i>Clostridioides difficile</i> infection severity.

mBio·2026

関連する実験動画

Updated: Jan 8, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

13.1K

クロストリディオイデス・ディフィシルにおけるエンテロコッカス・フェカリスによる相変異の調節

Ashley S Weiss1,2, Jilarie A Santos-Santiago3, Orlaith Keenan1,2

  • 1Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Journal of bacteriology
|December 23, 2025
PubMed
まとめ
この要約は機械生成です。

エンテロコッカス・フェカリスはクロストリディオイデス・ディフィシルの相変異に影響を与え、その集団の不均一性を変化させる。この相互作用はC. difficileの表現型に影響を与え、病原体の適応と持続における多菌種環境の役割を強調する。

キーワード:
コロニー形態相変異多菌種相互作用表面運動性

さらに関連する動画

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

9.3K
Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
09:49

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

2.7K

関連する実験動画

Last Updated: Jan 8, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

13.1K
A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

9.3K
Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
09:49

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

2.7K

科学分野:

  • 微生物学
  • 病原体-宿主相互作用
  • 微生物生態学

背景:

  • クロストリディオイデス・ディフィシルのような腸内病原体は、適応のために相変異を利用する。
  • 腸内細菌叢が病原体の不均一性に与える影響は十分に研究されていない。
  • エンテロコッカス・フェカリスはC. difficileと腸内で共感染する。

研究 の 目的:

  • エンテロコッカス・フェカリスがクロストリディオイデス・ディフィシルの相変異にどのように影響するかを調査すること。
  • C. difficile集団の不均一性に対する多菌種相互作用の影響を探求すること。

主な方法:

  • E. faecalisとC. difficileを固形培地上で一緒に培養すること。
  • C. difficileのコロニー形態と細胞特性の変化を観察すること。
  • 表現型のシフトにおけるCmrRSTシグナル伝達システムの役割を分析すること。

主要な成果:

  • E. faecalisは、CmrRST相変異に関連するC. difficileの表現型を著しく変化させた。
  • E. faecalisはC. difficileにおける「cmr-ON」状態へのスイッチを促進し、細胞連鎖と粗いコロニーを引き起こした。
  • この効果はE. faecalisに特異的であり、他の試験された細菌は同様の影響を示さなかった。

結論:

  • 多菌種環境、特にE. faecalisの存在は、C. difficile集団の不均一性に критически 影響を与える。
  • 微生物生態学と相互作用は、病原体の表現型変動の形成において複雑な役割を果たす。
  • これらの相互作用を理解することは、C. difficile感染症の新しい治療標的を明らかにする可能性がある。