Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Cluster replicability in single-cell and single-nucleus atlases of the mouse brain.

Nature communications·2026
Same author

Generative Principal Component Regression via Variational Inference.

IEEE transactions on signal processing : a publication of the IEEE Signal Processing Society·2026
Same author

Acylglycerol kinase contributes to cell proliferation by activating NF‑κB signaling pathway in pancreatic cancer.

Oncology reports·2026
Same author

On the state of protein function prediction: a report on the fourth CAFA challenge.

bioRxiv : the preprint server for biology·2026
Same author

Dissociable, species-specific impact of Aβ on static and dynamic functional connectomes.

bioRxiv : the preprint server for biology·2026
Same author

Cell type-agnostic transcriptomic signatures enable uniform comparisons of neural maturation.

PLoS biology·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Correlates and predictors of self-efficacy among dementia caregivers: D-CARE findings.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

What should convince a clinician of disease modification in Alzheimer's disease clinical trials?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Primary cilia-extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
関連記事をすべて見る

関連する実験動画

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基礎科学と病態生理

Lauren A Fish1, Saranya Canchi1, Maria Telpoukhovskaia2

  • 1University of Michigan, Ann Arbor, MI, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
まとめ
この要約は機械生成です。

研究者らは、多様なマウスモデルを用いて、アルツハイマー病（AD）における認知的回復力に関連する遺伝子発現シグネチャを特定した。この発見は、特定の神経経路を標的とすることにより、効果的なAD治療法の開発に向けた新しい道を提供する。

キーワード:
アルツハイマー病認知的回復力遺伝子発現マウスモデル神経科学トランスクリプトーム解析治療標的

さらに関連する動画

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

関連する実験動画

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学分野:

  • 神経科学
  • 遺伝学
  • 薬理学

背景:

  • ADの創薬開発は、動物モデルの限界により課題に直面している。
  • 遺伝的に多様なAD-BXDマウスモデルは、ヒトADを反映した変動する発症と認知低下を示す。
  • 以前の研究で、興奮性ニューロンにおける回復力遺伝子発現シグネチャが同定された。

研究 の 目的:

  • AD回復力に関連する新規の保存された遺伝子発現シグネチャおよびニューロンサブタイプを同定すること。
  • マウスとヒトのトランスクリプトームデータを統合し、翻訳的に関連性のあるアノテーションを行うこと。
  • 連続的な認知回復力指標を用いて、ニューロンサブクラスにおける差次的遺伝子発現を解析すること。

主な方法:

  • AD-BXDマウスのシングルニューロントランスクリプトームデータをヒトROSMAPデータと統合した。
  • ヒト細胞分類を用いてマウス細胞にアノテーションを付与した。
  • 恐怖条件付け課題を共変量として、ニューロンサブクラスにおける差次的遺伝子発現解析を実施した。

主要な成果:

  • 連続的な認知指標は、カテゴリカルな指標よりも差次的遺伝子発現解析において高い統計的検出力を示した。
  • 興奮性および抑制性ニューロンサブタイプにおいて差次的遺伝子発現遺伝子（DEG）を同定した。
  • 層2/3興奮性ニューロンで最も多くのDEGが示され、その中にはADリスクに関連するSCG5が含まれていた。

結論:

  • 遺伝的に多様なADマウスモデルにおいて、認知的回復力に関連するトランスクリプトームシグネチャが同定された。
  • 種を超えた保存された回復力シグネチャと細胞タイプの調査が進行中である。
  • 将来の解析では、前臨床検証のための薬剤標的の特定と再配置に焦点を当てる。