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Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

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Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
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Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
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アルツハイマー病イメージングコンソーシアム

Mahir Tazwar1, Arnold M Evia2, Abdur Raquib Ridwan2

  • 1Illinois Institute of Technology, Chicago, IL, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
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まとめ
この要約は機械生成です。

研究者らは、Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change（LATE-NC）の自動MRIベースマーカーであるMARBLEを開発しました。このツールは、高齢者におけるLATE-NCの生体内診断とモニタリングの可能性を示しています。

キーワード:
アルツハイマー病イメージングMRI診断高齢者TDP-43神経変性疾患

さらに関連する動画

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
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Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

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Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
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Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
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Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
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科学分野:

  • 神経学
  • 神経画像
  • 老年医学

背景:

  • Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change（LATE-NC）は、加齢に伴う脳で一般的に見られる所見ですが、確定診断には剖検が必要です。
  • 現在の診断上の限界は、LATE-NCのタイムリーな介入と研究を妨げています。

研究 の 目的:

  • LATE-NCの生体内磁気共鳴画像法（MRI）マーカーを開発および検証すること。
  • 神経画像の特徴を用いたLATE-NC診断のための自動ツールの作成。

主な方法:

  • 縦断的加齢研究からの病理と、生体外および生体内のMRIデータを利用しました。
  • 異方性分画、変形ベース形態測定、および葉体積を使用した2レベルスタッキング分類器を開発しました。
  • 分類器をMARBLE（MARker of Brain LatE）という自動ソフトウェアコンテナにパッケージ化しました。

主要な成果:

  • 生体外分類器はAUC 0.85、バランス精度77%を達成しました。生体内検証ではMARBLEマーカーはAUC 0.76を示しました。MARBLEスコアが高いほど、LATE-NCの進行段階と有意に関連していました（p < 0.001）。

結論:

  • MARBLEは、LATE-NCの新規の自動生体内MRIマーカーです。
  • このツールは、生体内診断とモニタリングにおいて有望なパフォーマンスを示しました。
  • 独立したコホートでのさらなる検証が必要ですが、MARBLEはLATE-NC管理の可能性を秘めています。