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Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

251
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
251
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

212
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
212
Brain Imaging01:14

Brain Imaging

629
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

460
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
460
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

758
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

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751

アルツハイマー病イメージングコンソーシアム

Hubert Leo1, Joshua L Gills2, Omonigho M Bubu2

  • 1New York University Langone Health, New York City, NY, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
まとめ
この要約は機械生成です。

この研究は、アルツハイマー病（AD）の血漿バイオマーカー（アミロイドβ（Aβ）やタウなど）を、高度なプラットフォームにわたる共通のプロテオームプロファイルに関連付け、AD診断を支援するものです。

キーワード:
アルツハイマー病血漿バイオマーカープロテオームSomaScanOlinkALAMARアミロイドβタウ神経変性疾患

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Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
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Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
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Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

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05:17

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Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

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Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
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科学分野:

  • 神経変性疾患のプロテオミクスとバイオマーカー発見。
  • アルツハイマー病（AD）バイオマーカーのプラットフォーム間検証。
  • AD病理に関連する分子経路の調査。

背景:

  • アミロイドβ（Aβ）やリン酸化タウ（p-tau）などの血漿バイオマーカーは、アルツハイマー病（AD）の評価に不可欠である。
  • SomaScan、Olink、ALAMARなどの高度なプロテオームプラットフォームは、精密なタンパク質定量化を可能にする。
  • 異なるプロテオーム測定値間の関係を理解することは、バイオマーカーの検証に不可欠である。

主な方法:

  • ARICコホートの116人の参加者の血漿サンプルを用いた横断的分析。
  • アルツハイマー病（AD）バイオマーカー（アミロイドβ（Aβ）、p-tau、神経線維軽鎖（NfL）、グリア線維性酸性タンパク質（GFAP）を含む）のALAMAR NULISAを用いた定量化。
  • ALAMARデータとSomaScan 11kおよびOlink 5kプロテオームデータの比較、およびプラットフォーム間相関と経路濃縮分析。

結論:

  • 複数のプロテオームプラットフォームにわたってアルツハイマー病（AD）バイオマーカーに関連する共通のプロテオームプロファイルが特定された。
  • ALAMAR ATNおよびI血漿バイオマーカーは、筋構造の完全性、炎症、腎機能、細胞膜の完全性に関連するタンパク質と中程度から強い相関を示した。
  • 今後の研究では、ADの連続体全体にわたる個人の組織特異的な経路を調査する必要がある。