公衆衛生
Julie Chandler1, Zachary Sheff1, Nalin Payakachat1
1Eli Lilly & Company, Indianapolis, IN, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
まとめ
アルツハイマー病(AD)が進行するにつれて、メディケアの支出は大幅に増加します。前臨床ADの早期特定と介入は、潜在的なコスト削減と患者転帰の改善に不可欠です。
科学分野:
- 老年医学; 神経科学; 保健経済学
背景:
- 前臨床アルツハイマー病(AD)の進行と医療資源利用(HRU)は、依然として十分に理解されていません。無症候性AD段階における臨床進行の早期指標を特定することが重要です。
主な方法:
- 246人の参加者について、メディケア請求データと無症候性ADにおける抗アミロイド治療(A4)研究からの転帰をリンクしました。臨床認知評価尺度(CDR-GS)およびメディケアデータ(認知障害の診断、ADの診断、JEN Frailty Index [JFI]≧6)を使用してADの進行を定義しました。ロジスティック回帰および線形回帰を使用して、ADの進行と診断、受診、および支払いとの関連を分析しました。
結論:
- アルツハイマー病が前臨床段階から症候性段階へと進行するにつれて、メディケアの支出は増加します。症候性ADへの進行を遅らせることに関連するコスト削減をさらに調査する必要があります。
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