Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

<i>Tetrapleura tetraptera</i> fruit phenolics fraction protects against the impact of ischemic stroke-induced hippocampal distortions and memory deficits in Wistar rats.

Anatomy & cell biology·2024
Same author

Aging impaired locomotor and biochemical activities in Drosophila melanogaster Oregon R (fruit fly) model.

Experimental gerontology·2024
Same author

Molecular and phylogenetic analysis of a type K1 strain <i>Trypanosoma evansi</i> isolate from Nigerian cattle: An evaluation of the therapeutic effects of compounds from <i>Brassica oleracea</i> on the histopathology of infected wister rats.

Biochemistry and biophysics reports·2023
Same author

Genistein and <i>Momordica charantia</i> L. prevent oxidative stress and upregulate proglucagon and insulin receptor mRNA in diabetic rats.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme·2021

関連する実験動画

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基礎科学と病態生理

Gbenga Peter Oderinde1, Solomon B Danborno2, Uduak Emmanuel Umana3

  • 1Ahmadu Bello University Zaria, Zaria, Kaduna, Nigeria.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
まとめ

オメガ3魚油とカンナビジオールの組み合わせは、睡眠不足によって引き起こされたラットの認知障害と海馬の損傷を効果的に逆転させた。この神経保護戦略は、酸化ストレスを軽減し、脳構造を回復させた。

キーワード:
睡眠不足認知機能海馬オメガ3脂肪酸カンナビジオール酸化ストレス神経保護ラット実験的治療

さらに関連する動画

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

関連する実験動画

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学分野:

  • 神経科学
  • 薬理学
  • 生化学

背景:

  • 睡眠不足は認知機能に悪影響を及ぼす世界的な健康問題である。
  • これまでの研究では、全体的な健康と認知パフォーマンスへの潜在的な悪影響が示唆されている。
  • 海馬のCA3領域は記憶に重要であり、睡眠不足に対して脆弱である。

研究 の 目的:

  • オメガ3魚油とカンナビジオールの併用投与による神経保護効果を調査する。
  • 睡眠不足誘発性の認知障害および海馬損傷への影響を評価する。
  • CA3領域における酸化ストレスマーカーおよび組織学的変化の調節を評価する。

主な方法:

  • 成体雄性Wistarラットを21日間、1日18時間の睡眠不足にさらした。
  • 実験群にはオメガ3魚油、カンナビジオール、またはそれらの組み合わせを投与した。
  • 認知機能はモリス水迷路を用いて評価し、その後、酸化ストレス分析および海馬組織学的検査を行った。

主要な成果:

  • 睡眠不足はモリス水迷路における潜時時間を有意に増加させ、空間記憶の低下を示した。
  • 併用治療群では、マロンジアルデヒドが減少し、抗酸化酵素（スーパーオキシドジスムターゼ、カタラーゼ、還元型グルタチオン）が増加した。
  • 組織学的検査により、睡眠不足群と比較して併用治療群でCA3海馬の組織構造が著しく回復したことが明らかになった。

結論:

  • オメガ3魚油とカンナビジオールの併用投与は、睡眠不足誘発性の認知障害に対して有意な回復効果を示した。
  • この併用療法は、脳内の酸化ストレスマーカーを効果的に減少させた。
  • 本研究は、睡眠不足関連の神経損傷に対する治療戦略としてのオメガ3とカンナビジオールの組み合わせの可能性を強調するものである。