公衆衛生
Sasha Milton1, Jiahe Wei2, Haizhen Chen2
1University of California, San Francisco, San Francisco, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
まとめ
休息・活動リズムの振幅または中央値の低下は、65歳以上の成人における認知症リスクの増加と関連している。これは、概日リズムの変化が認知症の早期発症の兆候となる可能性を示唆している。
科学分野:
- クロノバイオロジー
- 神経科学
- 疫学
背景:
- 概日リズムの乱れが認知症リスクと関連するというエビデンスが増加している。
- 概日リズムの変化の正確な役割(リスク因子か前兆マーカーか)は、特に異なる年齢層において不明確である。
- 中年期から老年期にかけてこの関連を調査することで、その関係を明確にすることができる。
主な方法:
- 42歳から78歳までの認知症のない英国バイオバンク参加者86,734人の手首アクチグラフィデータの分析。
- 休息・活動リズム(RAR)パラメータ(振幅、中央値、擬似F値)の計算。
- 年齢層(65歳以下、66〜70歳、70歳超)への層別化と、共変量を調整したコックスモデルを用いたインシデントACDリスクの比較。
結論:
- 休息・活動リズムの振幅と中央値の低下は、65歳以上の成人における全死亡性認知症リスクの増加と関連している。
- 概日リズムの乱れは、高齢者集団における認知症の前兆マーカーとして機能する可能性がある。
- これらの発見は、老化と認知症予防における概日リズムの健康の重要性を強調している。
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