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公衆衛生

Debora Melo van Lent1,2, Daniel Koijs3,4,5, Josh Bis6

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まとめ
この要約は機械生成です。

地中海食-DASH介入による神経変性遅延（MIND）食への準拠は、認知症のリスク低下と関連している。MIND食スコアが高いほど、80歳で認知症を発症せずに生存している可能性が高まる。

キーワード:
公衆衛生認知症MIND食地中海食DASH食神経変性食事療法疫学リスク因子高齢者

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科学分野:

  • 神経科学
  • 栄養科学
  • 疫学

背景:

  • 観察研究では、地中海食-DASH介入による神経変性遅延（MIND）食と認知症リスクの低下との関連が示唆されている。
  • MIND食は、地中海食とDASH食の側面を組み合わせ、脳に良い食品に焦点を当てている。

研究 の 目的:

  • MIND食スコアと、新たに発症する全原因認知症のリスクとの関連を調査すること。
  • MIND食スコアと、80歳で生存かつ認知症を発症していない確率との関連を調べること。

主な方法:

  • 6つの地域ベースコホートから得られた、認知症を発症していない8,714人の成人データを分析した。
  • Cox比例ハザードモデルとロジスティック回帰モデルを使用し、結果をメタアナリシスで統合した。
  • MIND食スコアは、10種類の健康的な食品成分と5種類の不健康な食品成分に基づいて計算された。

主要な成果:

  • MIND食スコアが高いほど、全原因認知症のリスク低下と関連していた（ハザード比=0.96、95%信頼区間=0.93-0.99）。
  • MIND食スコアが6以上の場合、認知症リスクの有意な低下が見られた（ハザード比=0.86、95%信頼区間=0.78-0.94）。
  • MIND食スコアが高いほど、80歳で生存かつ認知症を発症していない可能性の向上と関連していた（オッズ比=1.11、95%信頼区間=1.07-1.15）。

結論:

  • MIND食は、全原因認知症のリスク低下と関連している。
  • MIND食への高い順守率は、80歳で認知症を発症せずに生存している可能性の向上と関連している。
  • MIND食と認知症の病態（アミロイドおよびタウマーカーを含む）との間の潜在的な因果関係をさらに探求するために、臨床試験の実施が推奨される。