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公衆衛生

Ingryd Mayara Nascimento Martins-Pais1, Carlos Fermín-Martínez2, Omar Bello-Chavolla3

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まとめ

生物学的年齢（AnthropoAge）が高いほど、世界中の高齢者の認知機能が低下する。この関連は、抗老化タンパク質であるクロトーによって媒介されなかった。

キーワード:
生物学的年齢認知機能低下高齢者クロトー老化

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科学分野:

  • 老年医学；認知神経科学；老化のバイオマーカー

背景:

  • 暦年齢は認知機能低下の主な危険因子ですが、老化の複雑さを完全には表していません。；人体の測定値を使用した新しい生物学的年齢の指標であるAnthropoAgeは、暦年齢よりも死亡率をより良く予測します。；抗老化タンパク質であるクロトーの老化における役割と、認知機能に対する老化の影響の潜在的な媒介は調査中です。

研究 の 目的:

  • 多様な高齢者集団におけるAnthropoAgeと認知機能との関連を調査すること。；抗老化タンパク質であるクロトーが、AnthropoAgeと認知機能との関連を媒介するかどうかを判断すること。

主な方法:

  • 複数の国際コホート（NHANES、HRS-HCAP、ELSA-HCAP、LASI-DAD、Mex-Cog）の高齢者（60歳以上）のデータを利用しました。；生物学的年齢を評価するために、簡略化されたAnthropoAge指標（年齢、BMI、ウエストと身長の比率）を採用しました。；記憶力、実行機能、言語流暢性に関する認知機能の評価を実施し、線形回帰およびクロトーを用いた媒介分析により関連を分析しました。

主要な成果:

  • 解析には、5つの国際コホートからの7,500人以上の参加者が含まれました。；生物学的年齢（AnthropoAge）が高いほど、評価されたすべての国で認知機能が低下することが統計的に有意に関連していました。；AnthropoAgeと認知機能との関連は、クロトーレベルによって媒介されませんでした。

結論:

  • AnthropoAgeによって示される生物学的年齢の上昇は、高齢者の認知機能の低下と相関しています。；影響を受けた特定の認知領域は国によって異なり、集団特有の老化パターンが強調されています。；クロトーは、AnthropoAgeと認知機能低下との関連を媒介しないように思われるため、代替経路が示唆されます。