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公衆衛生

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まとめ
この要約は機械生成です。

円錐指数（CI）で測定される腹部肥満度が高いほど、成人における認知軌跡の悪化と関連していた。これは、中心性肥満が認知低下の修正可能な危険因子であることを示唆しており、特に女性および若年者において顕著である。

キーワード:
腹部肥満認知軌跡円錐指数修正可能な危険因子認知低下

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科学分野:

  • 老年学；疫学；公衆衛生

背景:

  • 軽度認知障害（MCI）および認知症は、世界的な健康上の大きな課題を提示している。
  • 円錐指数（CI）によって定量化される腹部肥満は、認知障害と関連している。
  • CIが認知軌跡に与える影響に関する縦断データは限られている。

研究 の 目的:

  • 円錐指数（CI）と2つの多様なコホートにおける認知軌跡との関連を調べること。
  • CIによって示される腹部肥満が認知低下の修正可能な危険因子であるかどうかを判断すること。

主な方法:

  • 西安農村住民認知コホート（XRRCC）および米国退職者調査（HRS）のデータを用いた後ろ向きコホート研究。
  • 潜在クラス成長モデル（LCGMs）は、正常なベースライン認知および少なくとも4回の調査データ（2014-2020）を持つ参加者の認知軌跡を特定した。
  • 多項ロジスティック回帰は、共変量に対する調整を行い、CI四分位数と認知軌跡との関連を分析した。

主要な成果:

  • 安定、悪化の2つの認知軌跡がXRRCC（n=1,452）で見られた。HRS（n=4,494）では、高、中、悪化の3つが見られた。
  • より高いCI値は、両コホートでより悪い認知軌跡と相関していた。
  • 最も高いCI四分位数は、最も低い四分位と比較して認知低下のオッズ増加と関連していた（XRRCC：OR=0.554；HRS：OR=0.725）。

結論:

  • CIの上昇は、特に女性および65歳未満の個人において、より不良な認知軌跡と関連していた。
  • CIによって測定される腹部肥満は、認知悪化の潜在的な修正可能な危険因子を表す。
  • 中心性肥満を標的とした早期介入は、認知低下の軽減に役立つ可能性がある。