関連する実験動画

Updated: Jan 8, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children

Published on: August 22, 2012

公衆衛生

Dvir Dori¹, Bruna Seixas Lima², Carlos Tyler Roncero²

¹Rotman Research Institute-Baycrest, TORONTO, ON, Canada.

Alzheimer's & dementia : the journal of the Alzheimer's Association

|December 23, 2025

要旨

Background:

Emerging hypotheses suggest that 'suboptimal' thyroid function, defined as higher-normal TSH (2.0-4.5 µIU/ml) or low-normal FT4, may increase the risk of cognitive decline and dementia.

Method:

This study tested these claims using data from 991 participants in the COMPASS-ND cohort, aged 50-91, with cognitive statuses ranging from unimpaired to dementia. Thyroid function was classified as "optimal" (TSH<2.0 µIU/ml or FT4≥16.74 pmol/L) or "suboptimal."

Result:

Chi-square analysis of 883 participants (523 with FT4 data) found no significant association between "suboptimal" thyroid function and cognitive impairment (TSH: χ²=0.1585, p = 0.69; FT4: χ²=0.0027, p = 0.96). True hypothyroidism was rare, and 98.6% of participants with elevated TSH had normal FT4 levels.

Conclusion:

These findings refute claims that higher-normal TSH or low-normal FT4 increases cognitive decline risk, highlighting the need for caution in redefining TSH cutoffs or pursuing unproven thyroid supplementation as a cognitive health intervention.

キーワード:

甲状腺機能認知機能低下公衆衛生疫学コホート研究

さらに関連する動画

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India

Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India

Published on: December 23, 2022

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

関連する概念動画

Primary Healthcare Services

Primary Healthcare Services

Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...

Levels of Health Promotion and Illness Prevention

Levels of Health Promotion and Illness Prevention

Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...

Preventive Healthcare Services

Preventive Healthcare Services

Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:

Principles of Disease Surveillance

Principles of Disease Surveillance

Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...

Healthcare Agencies II

Healthcare Agencies II

There are various healthcare agencies in the United States—some of which are managed by religious institutions and others by different government branches.
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...

Methods Of Healthcare Delivery System

Methods Of Healthcare Delivery System

At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...