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Primary Healthcare Services01:30

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Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
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Preventive Healthcare Services01:30

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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
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公衆衛生

Jiafeng Wang1,2, Xiaoyu Wang3, Qianqian Xie3

  • 1Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

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まとめ
この要約は機械生成です。

脈絡叢（ChP）の容積は、高齢者、特に男性および70歳未満の認知機能低下と逆U字型の関連を示した。この関連は、脳室および内側側頭葉の萎縮によって部分的に説明される。

キーワード:
公衆衛生脈絡叢認知機能低下MRI高齢者男性加齢脳室側頭葉萎縮

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科学分野:

  • 神経画像
  • 老年医学
  • 脳脊髄液動態

背景:

  • 脈絡叢（ChP）は脳脊髄液（CSF）を生成し、血液脳脊髄液関門を形成する。
  • 高齢者集団における認知機能低下におけるその役割は、さらなる調査が必要である。

研究 の 目的:

  • 高齢者における脈絡叢（ChP）容積と認知機能低下の縦断的関連を調べること。
  • この関連における潜在的な媒介要因を探求すること。

主な方法:

  • 人口ベースのコホート研究（認知症のない高齢者176名、60歳以上）。
  • 脈絡叢（ChP）容積のセグメンテーションのための磁気共鳴画像法（MRI）。
  • 経時的（2014年、2018年、2021年）な認知評価のためのミニメンタルステート検査（MMSE）。
  • 混合効果線形モデルおよび媒介分析モデルを用いた統計解析。

主要な成果:

  • 脈絡叢（ChP）の容積と認知機能低下（MMSEスコア低下）の間には、逆U字型の関係が観察された。
  • この関連は、男性および70歳以上の個人でより顕著であった。
  • 下外側脳室（ILV）の容積と内側側頭葉の萎縮の定量化（QMTA）が、ChP容積の増加と認知機能低下の関連を部分的に媒介した。

結論:

  • 脈絡叢（ChP）容積は、全体的な認知機能低下と逆U字型の関連を示す。
  • この関連は、男性および若年高齢者（70歳未満）で有意である。
  • 下外側脳室（ILV）の容積および内側側頭葉の萎縮の定量化（QMTA）は、この関連の有意な媒介因子である。