公衆衛生
Victoria Mery1,2, Chloe Walsh1,3,4, Antigone Fogel1,2
1Imperial College London, London, United Kingdom.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
まとめ
視覚障害(VI)は認知症リスクと関連している。視覚障害や水晶体疾患などのVI状態の早期診断と管理は、認知症予防に役立つ可能性がある。
科学分野:
- 眼科学; 神経学; 老年医学
背景:
- 未治療の視力喪失(VI)は、後期認知症の修正可能なリスク因子です。 高齢化人口におけるVIと認知機能低下の関係は、さらなる調査が必要です。
研究 の 目的:
- 大規模コホートにおける視覚障害の併存疾患と認知症との関連を分析すること。 認知症患者におけるVIの有病率、パターン、および重症度を理解すること。
主な方法:
- 電子カルテを使用した2つの認知症コホート(UKバイオバンクおよびAll of Us)の症例対照分析。 国際疾病分類第10版(ICD-10)コードを使用してVIの状態を特定しました。 Mann Whitney-U検定により、認知症患者と対照群の間でVIの有病率を比較し、診断ブロック数と最初のVI診断年齢を分析しました。
主要な成果:
- 視覚障害および失明は、認知症群(UKB、AoUS)でより一般的でした。 「筋肉、運動、調節および屈折」および「水晶体疾患」のVIの早期診断は認知症と関連していました。 最初のVI診断から認知症発症までの期間は、血管性認知症よりもアルツハイマー病の方が短い傾向がありました。
結論:
- 特定のVI診断と認知症との間には有意な関連が存在します。 VI状態の早期管理は、認知症予防戦略として支持されています。
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