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公衆衛生

Margaret McGregor1, Jordan Zaenglein1, Solymar Rivera-Torres1

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まとめ
この要約は機械生成です。

集中治療（IPAT）研究における収縮期血圧は、病院データベースが募集に最も効果的であると判断した。興味のある多くの個人は、収縮期血圧（SBP）が130 mmHg未満であるため除外された。

キーワード:
高血圧高齢者募集戦略臨床試験除外基準

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科学分野:

  • 神経学
  • 心血管医学
  • 臨床試験

背景:

  • 収縮期血圧の集中治療が脳灌流、アミロイド、タウに与える影響（IPAT）研究は、集中的な血圧治療の効果を調査する。
  • このランダム化比較試験は、高血圧（SBP>130 mmHg）の高齢者（60〜85歳）を対象とする。
  • ポジトロン放出断層撮影（PET）を使用して、脳のアミロイドとタウへの影響を評価することを目的とする。

研究 の 目的:

  • IPAT研究の募集戦略の有効性を評価する。
  • 参加者除外の主な理由を特定する。
  • 高血圧を対象とする臨床試験の将来の募集を最適化する。

主な方法:

  • 募集は、病院データベース（MyChart）、マーケティングメール、およびコミュニティアウトリーチイベントを利用した。
  • 1735人を電話スクリーニングし、2年間（2022年10月〜2024年11月）で140人が同意した。
  • 除外基準は、主に収縮期血圧（SBP）<130 mmHgおよびMRI / PETスキャンを受けられないことであった。

主要な成果:

  • 病院データベースは最も高いランダム化率（31％）をもたらした。
  • 主要な除外理由には、SBP <130 mmHg（スクリーニング390人、同意13人）および参加者の関心の欠如（スクリーニング254人）が含まれた。
  • 同意した参加者は主に非ヒスパニック白人（80％）で、高学歴（88％）であった。

結論:

  • 病院データベースはIPAT研究の募集に効果的である。
  • 現在の戦略は、血圧が良好に管理されている個人の過剰募集につながる可能性がある。
  • 将来の募集では、マイノリティや地方のコミュニティなど、血圧管理へのアクセスが限られている、十分にサービスが行われていない集団を対象とする必要がある。