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Updated: Jan 8, 2026

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury
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慢性代謝ストレスへの肝臓の適応 腫瘍発生

Constantine N Tzouanas1, Jessica E S Shay2, Marc S Sherman3

  • 1Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Harvard-MIT Program in Health Sciences and Technology, Harvard Medical School, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.

Cell
|December 23, 2025
PubMed
まとめ

慢性的なストレスは 生き残った肝細胞を変化させ 機能を低下させながら 発育や癌のプログラムを活性化します 特定の調節因子によって引き起こされる これらの細胞の変化は 将来の肝臓の腫瘍形成と疾患を 引き起こします

キーワード:
慢性的なストレス反応計算方法の開発エピジェネティック・プライミング遺伝的障害肝臓メタボリズム単細胞ゲノム組織記憶

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