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Synthetic Biology02:55

Synthetic Biology

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
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Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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Cis-regulatory Sequences02:02

Cis-regulatory Sequences

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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DNA as a Genetic Template02:05

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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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DNA as a Genetic Template02:05

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Automated Robotic Liquid Handling Assembly of Modular DNA Devices
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DNA-Diffusionという生成AIフレームワークを用いた合成調節因子の設計

Lucas Ferreira DaSilva1,2, Simon Senan2,3, Judith F Kribelbauer-Swietek4,5,6

  • 1Department of Pathology, Harvard Medical School, Boston, MA, USA.

Nature genetics
|December 24, 2025
PubMed
まとめ
この要約は機械生成です。

DNA-Diffusionは、細胞型特異的な活性を持つコンパクトな遺伝子調節因子の設計を可能にするAIフレームワークです。これにより、精密な遺伝子制御による合成生物学と遺伝子治療の進歩が期待されます。

キーワード:
合成生物学遺伝子治療AI調節因子ゲノム工学

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Designing a Bio-responsive Robot from DNA Origami
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科学分野:

  • ゲノミクス
  • 合成生物学
  • 人工知能

背景:

  • 調節エレメントによる遺伝子発現の精密制御は、重要な課題です。
  • 既存の方法では、機能活性、細胞型特異性、および配列多様性のバランスをとることが困難です。

研究 の 目的:

  • 新規調節エレメントの設計のための生成AIフレームワークであるDNA-Diffusionを導入すること。
  • コンパクトな合成エレメントを用いて、細胞型特異的な遺伝子発現制御を達成すること。

主な方法:

  • DNAアクセス可能性データで訓練されたAIフレームワークであるDNA-Diffusionを開発しました。
  • 内因性の転写因子結合を模倣する200塩基対の合成エレメントを生成しました。
  • 3つの細胞株におけるSTARR-seqおよび内因性遺伝子変調のためのEXTRA-seqを用いてエレメントを検証しました。

主要な成果:

  • DNA-Diffusionは、細胞型特異性を高めたコンパクトなエレメントを生成しました。
  • 合成エレメントは、内因性の転写因子結合文法を再現しました。
  • AXIN2遺伝子をネイティブコンテキストで再活性化し、機能的変調を実証しました。

結論:

  • DNA-Diffusionは、調節エレメントの設計において既存の計算方法よりも優れた性能を発揮します。
  • このフレームワークは、遺伝子治療における精密な遺伝子制御の工学に不可欠です。
  • 遺伝子制御の理解と新規治療戦略の開発を進歩させます。