Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Understanding Memory01:19

Understanding Memory

1.3K
Memory is the retention of information or experiences over time, facilitated through three main processes: encoding, storage, and retrieval. Encoding is the process of inputting information into the memory system. For instance, when listening to a lecture, watching a play, reading a book, or having a conversation, the brain is actively encoding information. This initial stage involves transforming sensory input into a form that can be processed and stored by the brain. Various factors, such as...
1.3K
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

2.6K
2.6K
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

8.6K
Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
8.6K
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

3.0K
3.0K
System of Memory01:23

System of Memory

7.1K
Memory is categorized into three major systems: sensory memory, short-term memory (STM), and long-term memory (LTM). These systems differ in their capacity and the duration for which they can hold information. Sensory memory captures raw sensory input from the environment, holding it for just a few seconds or less. For example, on hearing a brief, loud sound, like a car horn honking, the sound seems to linger in the mind for a moment even after it stops. This is an instance of sensory memory...
7.1K
Long-term Potentiation01:35

Long-term Potentiation

58.1K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
58.1K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Forest management and species identity shape climate sensitivity and drought resilience in temperate mountain forests.

Journal of environmental management·2026
Same author

Domain Coordination Governs Pore Architecture in Transient Double-Network Antibody-Binding Polyprotein Hydrogels.

ACS biomaterials science & engineering·2026
Same author

Precise Alternation Between Image-Forming Sample Planes Enables Quantitative Monitoring of Receptor-Arrestin Interaction Dynamics at the Plasma Membrane of Live Cells.

bioRxiv : the preprint server for biology·2026
Same author

Conformation-driven mechanical duality: Viscoelastic and poroelastic switching in protein hydrogels.

Acta biomaterialia·2026
Same author

Protein Biomaterials with Muscle-like Water-Driven Actuation.

ACS applied materials & interfaces·2026
Same author

Intensity-Based Estimation of Monomeric Brightness for Fluorescent Proteins.

International journal of molecular sciences·2025
Same journal

TDP-43 proteinopathy as a biomarker and therapeutic target in amyotrophic lateral sclerosis.

Biochemical Society transactions·2026
Same journal

Advancing the monitoring of organelle contact sites in vitro and in vivo.

Biochemical Society transactions·2026
Same journal

Mechanisms influencing transient cytoplasmic protein targeting to intracellular lipid droplets.

Biochemical Society transactions·2026
Same journal

Replication associated nuclear DNA mismatch repair across kingdoms.

Biochemical Society transactions·2026
Same journal

Phosphatases of regenerating liver downregulate PTEN to promote tumorigenesis.

Biochemical Society transactions·2026
Same journal

Implications of Rho GTPase signaling in cancer immunotherapy.

Biochemical Society transactions·2026
関連記事をすべて見る

関連する実験動画

Updated: Jan 8, 2026

Gradient Echo Quantum Memory in Warm Atomic Vapor
10:00

Gradient Echo Quantum Memory in Warm Atomic Vapor

Published on: November 11, 2013

13.1K

フォースは記憶を書き込む：分子記憶スイッチとしてのプロリン異性化

Ionel Popa1, Ronen Berkovich2

  • 1Department of Physics and Astronomy, University of Wisconsin-Milwaukee, Milwaukee, WI, 53211, U.S.A.

Biochemical Society transactions
|December 24, 2025
PubMed
まとめ
この要約は機械生成です。

機械的力は、タンパク質の展開と再折り畳みを通じて細胞記憶を可能にする。プロリン異性化は、生体材料およびバイオロボティクスに不可欠な適応性機械記憶を作成する。

キーワード:
生物物理学細胞内シグナル伝達学習と記憶力学変換プロリン異性化タンパク質ダイナミクス

さらに関連する動画

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
10:31

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability

Published on: February 3, 2022

3.4K
Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes
08:07

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes

Published on: March 9, 2019

8.3K

関連する実験動画

Last Updated: Jan 8, 2026

Gradient Echo Quantum Memory in Warm Atomic Vapor
10:00

Gradient Echo Quantum Memory in Warm Atomic Vapor

Published on: November 11, 2013

13.1K
Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
10:31

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability

Published on: February 3, 2022

3.4K
Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes
08:07

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes

Published on: March 9, 2019

8.3K

科学分野:

  • 生物物理学
  • メカノバイオロジー
  • 材料科学

背景:

  • 機械的力は細胞機能の重要な調節因子である。
  • 細胞は、機械的合図の影響を受ける分子記憶の一形態を示す。
  • 負荷下のタンパク質ダイナミクスは、細胞応答を理解するための鍵である。

研究 の 目的:

  • 細胞における機械的記憶のメカニズムをレビューする。
  • 機械的記憶におけるタンパク質の展開/再折り畳みの役割を探る。
  • プロリン異性化を記憶の重要な分子スイッチとして強調する。

主な方法:

  • 実験データと分子動力学シミュレーションを統合した文献レビュー。
  • 引張荷重下でのタンパク質の展開と再折り畳みの分析。
  • 機械的記憶のメカニズムとしてのプロリン異性化に焦点を当てる。

主要な成果:

  • タンパク質の展開と再折り畳みは、履歴依存性の細胞応答を生み出す。
  • プロリン異性化は、準安定状態を作成する可逆スイッチとして機能する。
  • このメカニズムは、中長期的な機械的記憶をサポートする。
  • 二値スイッチとは異なる、段階的で適応性のある記憶応答が提案されている。

結論:

  • プロリン異性化は、細胞の機械的記憶のフレームワークを提供する。
  • このメカニズムは、生体材料およびソフトロボットの設計に重要な意味を持つ。
  • 組織工学およびロボット工学のために、記憶特性を持つ力応答性材料を開発できる。