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Updated: Jan 8, 2026

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
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単一細胞タンパク質定量データからシグナル伝達ネットワークを再構築および比較する

Tim Stohn1,2, Roderick van Eijl3, Klaas W Mulder3

  • 1Department of Computer Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Bioinformatics (Oxford, England)
|December 24, 2025
PubMed
まとめ

新しい計算手法である単一細胞モジュラー応答解析（scMRA）および単一細胞比較ネットワーク再構築（scCNR）により、単一細胞タンパク質データからのシグナル伝達ネットワーク解析が可能になる。これらのアプローチは、標的がん治療を導くための細胞集団特異的なシグナル伝達の違いを明らかにする。

キーワード:
単一細胞シグナル伝達ネットワークネットワーク再構築プロテオミクス計算生物学

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Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
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